How Long Does It Take for CBD Oil to Work for Pain, Anxiety and Depression?

Lifelong Hempby Lifelong Hemp Last updated March 21, 2019
How Long Does It Take for CBD Oil to Work?

Scientific researches have shown several pieces of evidence on the efficacy of CBD and will suffice to say, CBD is a rich molecule that may benefit the human body.

Though THC (Tetrahydrocannabinol) is a chemical compound that is dominant in marijuana and causes a “high,” CBD contains only 0.3% THC that conveys therapeutic benefits without causing a psychotropic effect.

The benefits of hemp oil is endless because of its  unique properties that may help boost the immune system and alleviate several ailments. It’s most likely confusing when you are new to a chain of CBD products, and to discern the product that will work best for you and how long it will take to work.

You can make a well-informed decision as we bring you to the knowledge of how long it takes for CBD oil to work for pain, anxiety and depression.

So, relax and keep reading…


How CBD oil interacts with the human body system?

CBD is processed into different forms and can be ingested in different ways, it all depends on the essence of its production.

CBD hemp oil is one of the forms of CBD produce. It is either ingested through the mouth or topically. However, when CBD is taken, it interacts with the human endocannabinoid system (ECS).

Endocannabinoid System [a list of receptors target]

The endocannabinoid system receives the transmitting signal from the cannabinoids in the body through the CB1 receptor dominant in the brain and the CB2 receptor found in the immune system.

A functioning endocannabinoid system produces cannabinoid naturally by itself. But the intake of CBD influences the endocannabinoid system to produce more cannabinoid for the benefit of the human body.


What are the factors that determine the effectiveness of CBD oil?

CBD oil is an active substance that is easily absorbed into the body system.

But the question is what determines the efficacy of CBD oil?

Like it was mentioned earlier, CBD oil can be used in different ways. It can either be vaped, or ingested sublingually, or topically.

Whichever way you use it, it takes a few minutes to a couple of hours before you feel the effect.

A time for CBD to take an effect

Well, …

… it depends on the amount of CBD oil served at a goal and the human body system involved. CBD works better in a well-functioning endocannabinoid system (ECS) than a faulty system. Aside that, an ECS may be functioning well, but our body chemical make-up is different.

Other factors to consider are, the time range at which it was used and method of ingestion. Some of the likely questions that may suggest answers to your curiosities are;

Was it the first thing you took in the morning, or it was taken after eating a heap of food?

According to research studies, CBD works better when taken on an empty stomach.

On the other hand, it was suggested that consuming CBD oil with food enables easy penetration in the bloodstream and increases its effectiveness.


The effectiveness of CBD oil following the ingesting methods

The action of CBD evaluates the potential benefits it offers through different methods of ingesting CBD. The effect of CBD on the receptors are responsible for numerous activities in the brain and immune system. CBD is a natural supplement that easily interacts with the body system through the ECS.  There are several means of ingesting CBD, depends on the method of ingestion recommended by the manufacturer of a product and preference.

CBD oil ingesting methods


The most effective way of ingesting CBD oil is vaping. This is done through the use of vape kit usually pen. It is very easy to vape and is safe. There is a considerable tendency of feeling the effect in less than 15 minutes when each vape is puffed. This method easily penetrates into the bloodstream and produces a faster result.

Sublingual method

Another effective way of ingesting CBD oil is the sublingual method through the use of CBD oil sprays or CBD concentrate. This is an easy way to get CBD absorbed into your body.

Once ingested under the tongue, it interacts fast with the endocannabinoid system and may give relief within a few minutes not more than 20 minutes. This method is one of the best way of getting CBD absorbed into the body system.

Topical application

When you apply CBD oil topically, it does not get absorbed into the body as fast as vaping and sublingual method. It is relatively slow, but takes a gradual process and offers a more prolonged effect. It might take up to 40 minutes or even more than 2 hours before you start feeling the effect.

Edibles or capsules

If you are looking for the most productive effect in CBD, edibles or capsule are the best option. Edibles comes in the form of gummies bear and when eaten, it passes through the digestive tract and penetrate into the bloodstream. It might take up to 30 minutes or more than an hour for it to get absorbed, but it is very efficient.


How to know when CBD is at work?

By the way…

How do you know whether CBD is working already or not?

The obvious way to know is, a feeling of relief on the ailment symptoms. Some people feel the effect as a weakening symptom that may demand rest. Some others might be, a rapid change in the physical appearance of the skin irritations or changes in the way you feel before using CBD.

Generally, CBD hemp oil is widely known for its benefits and how it has helped alleviate some health issues.


How long does it take CBD to work for pain?

A large percentage of people suffer from chronic body pain, whether as a result of inflammation or pain associated with diseases. Old age is another factor that comes with several ailments that causes pain in the body.

So, at one point or the other…

…the body may be subjected to pain or joint pain.

American Academy of Pain Medicine (AAPM) has confirmed that most American suffer from chronic pain than Heart diseases, diabetes, and the likes.

Moreso, any inflamed part of the body comes with pain, and some pain can only be managed especially the one associated with old age.

Chronic pain statistics according to The American Academy of Pain Medicine

However, recent studies shows that CBD oil plays a significant role in alleviating chronic pain. When CBD oil is taken, it interacts with the ECS which may help to regulate specific hormone such as pain, immune system responses, sleep and so on.

Note, the ECS is topically active in controlling pain, and the CB2 receptor plays a major role in the immune system by managing inflammation and pain. CBD contains antioxidant and neuroprotective properties. All these properties are the backbone of CBD that enables it to act effectively.

While introducing CBD into your body for pain relief, you can choose to apply it topically to the affected area. It makes way for easy penetration directly on the specific area though, not usually fast. You can equally ingest it through capsule or the sublingual method.

So then, what length of time will it take CBD to work for pain?

Depending on the body system, especially the amount you start with and the mode of use, as soon as CBD is taken, it might take up to 30 minutes to an hour before you feel changes in the pained area.

Topical application last longer while edibles or capsule is an alternative means of taking CBD for pain. At least, CBD trace last 3 to 4 days in the body while the effect might last up to 4 to 6 hours.

How long does it take CBD to work for pain?

An article review on pain management established the efficacy of cannabinoid analgesic following recent research and a clinical trial in pain management.

Muscle spasm is another cause of pain which is associated with multiple sclerosis.

A proper use of CBD for a short period was confirmed to help muscle spasm, but an overdose may worsen it. There is pain associated with arthritis, and people use CBD to alleviate such pain.


How long does it take CBD to work for anxiety?

For some reasons, a larger percentage of people suffer from anxiety.

Several health issues are associated with anxiety such as anxiety disorder, panic disorder, post-traumatic stress disorder, social anxiety, and obsessive-compulsive disorder.

There are pharmaceutical medications that have been invented to get rid of anxiety, yet they come with side effects that demand necessary precautions.

Types of Anxiety

Apart from the anxiety a lot of individuals suffer due to stress after working round the clock; anxiety disorder is a complicated issue that brings sleepless night, phobia, fear of the unknown and a lot more…

Social anxiety disorder is common among anxiety condition, and if you think you need help aside from medications, a natural product is a good option to consider.

Cannabidiol is a non-euphoria phytocannabinoid that may reduce anxiety and cognitive impairment. According to research studies and clinical trials, a group of people suffering from anxiety was given CBD while some were given placebo. It was discovered that pre-treatment with CBD reduced anxiety and there was an improvement in speech performance, while the placebo group presented the opposite.

The target of CBD is to boost the serotonin receptor in the synaptic space for an increase in signals that are transmitted to the brain cell. CBD activates the 5-HT1A (hydroxytryptamine) serotonin receptor directly, thereby releasing the anti-anxiety effect. This may help to enhance your mood and reduce anxiety. Several studies have shown the effectiveness of CBD, but do not affect the psychological state of its consumer.

More so…

…anxiety can bring tension and lack of motivation, but CBD contains therapeutic and nutritional properties that can promote relaxation and improve your state of mind.

However, CBD mworks better through vaping or the sublingual method.

How long does it take CBD to work for anxiety?

The duration of time at which CBD works for anxiety is under 20 minutes to an hour.

There should certainly be a difference in the way you feel. The specific time range at which CBD work for anxiety is yet to be figured out consideration several contributory factors like individual body differences.


How long does it take CBD to work for depression?


Depression is a pathological disease related to anxiety, and it deals with emotions and the state of mind. Are you aware that, over a million people suffer from depression worldwide.

Depression could be inborn or might be caused by trauma derived from an unfortunate circumstance.

Some of the symptoms of depression are suicidal thought, uncontrolled anger issues, irritations, insecurity, restlessness, sleeplessness, feeling empty, loneliness, increased or decreased appetites and weight loss.

Depression signs and symptoms

Based on research studies, CBD oil may be a reliable remedy for depression and may regulate human responses to stress. Endocannabinoid system is an important regulator of stress, and it influences certain activities in the brain.

When CBD oil is ingested, it interacts with serotonin and dopamine receptor (happiness hormone) which may help to regulate your mood and human social behavior.

The hippocampus, a limbic system located in the brain helps to regulate emotions. The effect of CBD oil on the other hand is,  to stimulate activities in the hippocampus by increasing the amount of calcium in the mitochondria (1).

It might take 6-8 weeks for an anti-depressant to unfold its effectiveness, whereas the time frame at which CBD works for depression may take more than a couple of hours.

How long does it take CBD to work for depression?

A 2006 study titled “Decreased depression in marijuana users” established, those who consume medical cannabis to alleviate depression had a less depressed mood. Another discovery proved that, it improved cognitive disorder in bipolar patients.

Despite the effect of CBD in the brain, it does not cause a “high,” but rather boost the hormone that influences a happy mood.

Fortunately, the world is revolving around natural supplement, especially now that most anti-depressant medicine comes with a side effect. There are many products out there given to the depressed, but most of them confer addictive effect.


Final Thought

CBD oil is an antipsychotic compound, containing ameliorating and potentially neuroprotective properties that can benefit the human health. The rate at which CBD penetrates into the body is based on the method of ingesting CBD.

According to research, the fastest means of getting CBD absorbed into the body system is vaping, the next is the sublingual method and lastly, through the digestive tract.

CBD oil certainly works for pain, depression and anxiety by interacting with a number of biological pathways to a wide range of effects. However, CBD can be administered through several methods, but the length it takes to work cannot be specifically stated.

Shop our most popular products


  • SSeadals

    People who I know that use the CBD actually claims their CBD works better taken on an empty stomach but for me it is with food. Definitely consuming CBD oil with food allows it to penetrate quickly into the bloodstream and increases its effectiveness. But still, not all methods works for everyone so you just have to know which works best for you.

    • Lifelong HempLifelong Hemp

      Hi Seadals,

      I’m glad to know that you are able to ingest CBD directly with your food. I know how important it is to know what works best for our body and health.
      It’s wonderful to know that you are able to absorb the nutrients on your food and anything that goes with it. Thank you so much for letting us know your best experiences and results of CBD.

      Have a nice day!

  • AAshlee

    Very informative article. Thanks for sharing!

    • Lifelong HempLifelong Hemp

      Hi Ashlee,

      I’m happy to know that you are learning quite a few things from our articles. Thank you for your time.

      Best regards,

  • JJane

    I am considering to switch to your hemp gels. How do I know if it is good for me? I have allergies to specific food, does this have to do with that?

    • Lifelong HempLifelong Hemp

      Hi Jane,

      I am happy to know that you are looking to try our soft gels. For your food allergy, it is always recommended for you to consult your physician if there’s a counter effect with CBD towards it. For our most recent lab tests, there was no positive effect on over the counter medicines versus cbd capsules. But to be sure, your health is our priority, and we always recommend for our customers to seek medical advice for such.
      I hope that you can try out our soft gels soon and enjoy the great results thereafter.

      Best regards,

  • JJemalyn

    What product do you recommend for a patient with sleeping disorders and depression? My sister in law is a bit worried about this and I want to help her.

    • Lifelong HempLifelong Hemp

      Hello Jemalyn,

      Thank you for showing interest in our products. As for your sister in law, I would recommend for her to try our CBD Concentrates, made from 100% pure and organic hemp. This one comes in 3 labels: Blue, Gold and Green. I’ve had a lot of customers saying that these products were able to help them with depression and insomnia. I hope that your sister in law feels better after trying this one.
      For dosage information and product label, please check this link:

      Best regards,

Leave a Comment

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.